[HTML][HTML] Rapid single-cell identification of Epstein–Barr virus-specific T-cell receptors for cellular therapy
MFL Cobo, C Welters, L Rosenberger, M Leisegang… - Cytotherapy, 2022 - Elsevier
Abstract Background and aims Epstein–Barr virus (EBV) is associated with solid and
hematopoietic malignancies. After allogeneic stem cell transplantation, EBV infection or
reactivation represents a potentially life-threatening condition with no specific treatment
available in clinical routine. In vitro expansion of naturally occurring EBV-specific T cells for
adoptive transfer is time-consuming and influenced by the donor's T-cell receptor (TCR)
repertoire and requires a specific memory compartment that is non-existent in seronegative …
hematopoietic malignancies. After allogeneic stem cell transplantation, EBV infection or
reactivation represents a potentially life-threatening condition with no specific treatment
available in clinical routine. In vitro expansion of naturally occurring EBV-specific T cells for
adoptive transfer is time-consuming and influenced by the donor's T-cell receptor (TCR)
repertoire and requires a specific memory compartment that is non-existent in seronegative …