[HTML][HTML] Antiviral T-cell frequencies in a healthy population: reference values for evaluating antiviral immune cell profiles in immunocompromised patients
FC Schulze Lammers, A Bonifacius… - Journal of clinical …, 2022 - Springer
Viral infections and reactivations are major causes of morbidity and mortality after
hematopoietic stem cell (HSCT) and solid organ transplantation (SOT) as well as in patients
with immunodeficiencies. Latent herpesviruses (eg, cytomegalovirus, Epstein-Barr virus, and
human herpesvirus 6), lytic viruses (eg, adenovirus), and polyomaviruses (eg, BK virus, JC
virus) can cause severe complications. Antiviral drugs form the mainstay of treatment for viral
infections and reactivations after transplantation, but they have side effects and cannot …
hematopoietic stem cell (HSCT) and solid organ transplantation (SOT) as well as in patients
with immunodeficiencies. Latent herpesviruses (eg, cytomegalovirus, Epstein-Barr virus, and
human herpesvirus 6), lytic viruses (eg, adenovirus), and polyomaviruses (eg, BK virus, JC
virus) can cause severe complications. Antiviral drugs form the mainstay of treatment for viral
infections and reactivations after transplantation, but they have side effects and cannot …
Antiviral T-cell frequencies in a healthy population: Reference values for evaluating antiviral immune cell profiles in immunocompromised patients and their …
A Bonifacius, FC Schulze Lammers… - Transfusion …, 2022 - pesquisa.bvsalud.org
Background: Viral infections and reactivations (eg cytomegalovirus (CMV)) are a major
cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT) and
solid organ transplantation (SOT) and in patients with immunodeficiencies. Here, antiviral
drugs are the mainstay of treatment, but they have side effects and cannot achieve complete
viral clearance without prior reconstitution of functional virus-specific T cells (VSTs). Method
(s) We performed serological testing and measured VST frequencies against 23 viral protein …
cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT) and
solid organ transplantation (SOT) and in patients with immunodeficiencies. Here, antiviral
drugs are the mainstay of treatment, but they have side effects and cannot achieve complete
viral clearance without prior reconstitution of functional virus-specific T cells (VSTs). Method
(s) We performed serological testing and measured VST frequencies against 23 viral protein …
