Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells
E Meedt, D Weber, A Bonifacius… - Clinical Infectious …, 2023 - academic.oup.com
E Meedt, D Weber, A Bonifacius, B Eiz-Vesper, B Maecker-Kolhoff, S Delecluse…
Clinical Infectious Diseases, 2023•academic.oup.comWe report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-
year-old female patient treated with third-party EBV-specific T cells followed by allogeneic
hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of
anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent
expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-
specific T cells.
year-old female patient treated with third-party EBV-specific T cells followed by allogeneic
hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of
anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent
expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-
specific T cells.
Abstract
We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-specific T cells.
Oxford University Press