Background Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of
antidepressants that block the serotonin transporter. Osteoblasts and osteocytes express
functional serotonin transporters; serotonin transporter gene disruption in mice results in
osteopenia; and SSRI use has been associated with increased risk of hip fracture. Methods
To determine whether SSRI use is associated with lower bone mineral density (BMD) in
older men and to compare the results for SSRIs with those of other antidepressants, we …