Background Serotonin transporters have recently been described in bone, raising the
possibility that medications that block serotonin reuptake could affect bone metabolism.
Methods We assessed current use of selective serotonin reuptake inhibitors (SSRIs) and
tricyclic antidepressants (TCAs) and obtained serial bone mineral density (BMD)
measurements in a cohort of 2722 older women (mean age, 78.5 years) participating in the
Study of Osteoporotic Fractures, a prospective cohort study of community-dwelling women …