[HTML][HTML] Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system
H Kondo, A Nifuji, S Takeda, Y Ezura, SR Rittling… - Journal of Biological …, 2005 - ASBMB
Osteoporosis is one of the major health problems in our modern world. Especially, disuse
(unloading) osteoporosis occurs commonly in bedridden patients, a population that is
rapidly increasing due to aging-associated diseases. However, the mechanisms underlying
such unloading-induced pathological bone loss have not yet been fully understood. Since
sympathetic nervous system could control bone mass, we examined whether unloading-
induced bone loss is controlled by sympathetic nervous tone. Treatment with β-blocker …
(unloading) osteoporosis occurs commonly in bedridden patients, a population that is
rapidly increasing due to aging-associated diseases. However, the mechanisms underlying
such unloading-induced pathological bone loss have not yet been fully understood. Since
sympathetic nervous system could control bone mass, we examined whether unloading-
induced bone loss is controlled by sympathetic nervous tone. Treatment with β-blocker …
