Tumour-infiltrating lymphocytes and interleukin-2 in treatment of advanced cancer
RL Kradin, DS Lazarus, SM Dubinett, J Gifford, B Grove… - The Lancet, 1989 - Elsevier
RL Kradin, DS Lazarus, SM Dubinett, J Gifford, B Grove, JT Kurnick, FI Preffer, CE Pinto…
The Lancet, 1989•ElsevierTumour-infiltating lymphocytes (TIL) were isolated and expanded from small tumour biopsy
samples of twenty-eight patients (thirteen with malignant melanoma, seven with renal cell
carcinoma, and eight with non-small-cell lung cancer). The patients were treated with
autologous expanded TIL (about 10 10) and continuous infusions of recombinant human
interleukin-2 (1-3 x 10 6 U/m 2 per 24 h). 29% of the patients with renal cell cancer and 23%
of those with melanoma achieved objective tumour responses lasting 3-14 months. Toxic …
samples of twenty-eight patients (thirteen with malignant melanoma, seven with renal cell
carcinoma, and eight with non-small-cell lung cancer). The patients were treated with
autologous expanded TIL (about 10 10) and continuous infusions of recombinant human
interleukin-2 (1-3 x 10 6 U/m 2 per 24 h). 29% of the patients with renal cell cancer and 23%
of those with melanoma achieved objective tumour responses lasting 3-14 months. Toxic …
Abstract
Tumour-infiltating lymphocytes (TIL) were isolated and expanded from small tumour biopsy samples of twenty-eight patients (thirteen with malignant melanoma, seven with renal cell carcinoma, and eight with non-small-cell lung cancer). The patients were treated with autologous expanded TIL (about 1010) and continuous infusions of recombinant human interleukin-2 (1-3 x 106 U/m2 per 24 h). 29% of the patients with renal cell cancer and 23% of those with melanoma achieved objective tumour responses lasting 3-14 months. Toxic side-effects were limited, and no patient required intensive-care monitoring. Adoptive immunotherapy with TIL and interleukin-2 may be an effective systemic approach to the treatment of some patients with malignant melanoma and renal cell carcinoma.
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