Association of ipilimumab with safety and antitumor activity in women with metastatic or recurrent human papillomavirus–related cervical carcinoma
S Lheureux, MO Butler, B Clarke, MC Cristea… - JAMA …, 2018 - jamanetwork.com
Importance Based on evidence of human papillomavirus (HPV)–induced immune evasion,
immunotherapy may be an attractive strategy in cervical cancer. Ipilimumab is a fully
humanized monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4 (CTLA-4),
which acts to downregulate the T-cell immune response. Objective To assess the safety and
antitumor activity of ipilimumab in recurrent cervical cancer. Design, Setting, and Participants
A multicenter trial was designed for patients with metastatic cervical cancer (squamous cell …
immunotherapy may be an attractive strategy in cervical cancer. Ipilimumab is a fully
humanized monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4 (CTLA-4),
which acts to downregulate the T-cell immune response. Objective To assess the safety and
antitumor activity of ipilimumab in recurrent cervical cancer. Design, Setting, and Participants
A multicenter trial was designed for patients with metastatic cervical cancer (squamous cell …