Radiotherapy, primarily known for its cytotoxic effect on the tumor cells, via the induction of
DNA damages, has the ability to induce a systemic antitumoral response. By an
immunologic cell death, tumor cells exposed to radiation release a large amount of
neoantigenes and pro-inflammatory mediators, acting as an in situ vaccine, resulting in an
tumor regression within the primary irradiated site, but also in the distant “out of field”
secondary tumors. However, this phenomenon is extremly rare with radiotherapy alone …