Bone metastases are a common occurrence in several malignancies, including breast,
prostate, and lung. Once established in bone, tumors are responsible for significant
morbidity and mortality1. Thus, there is a significant need to understand the molecular
mechanisms controlling the establishment, growth and activity of tumors in bone. Several in
vivo models have been established to study these events and each has specific benefits and
limitations. The most commonly used model utilizes intracardiac inoculation of tumor cells …