[HTML][HTML] The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in β cells but not in α cells and are also observed in human islets
P Detimary, S Dejonghe, Z Ling, D Pipeleers… - Journal of Biological …, 1998 - ASBMB
Glucose metabolism by pancreatic β and α cells is essential for stimulation of insulin
secretion and inhibition of glucagon secretion. Studies using rodent islets have suggested
that the ATP/ADP ratio serves as second messenger in β cells. This study compared the
effects of glucose on glucose oxidation ([U-14 C] glucose) and adenine nucleotides
(luminometric method) in purified rat α and β cells. The rate of glucose oxidation at 1 mm
glucose was higher in β than α cells (4.5-fold, ie∼ 2-fold after normalization for cell size). It …
secretion and inhibition of glucagon secretion. Studies using rodent islets have suggested
that the ATP/ADP ratio serves as second messenger in β cells. This study compared the
effects of glucose on glucose oxidation ([U-14 C] glucose) and adenine nucleotides
(luminometric method) in purified rat α and β cells. The rate of glucose oxidation at 1 mm
glucose was higher in β than α cells (4.5-fold, ie∼ 2-fold after normalization for cell size). It …