Bile acid-independent effect of hymecromone on bile secretion and common bile duct motility
RM Hoffmann, G Schwarz, C Pohl… - Deutsche …, 2005 - europepmc.org
RM Hoffmann, G Schwarz, C Pohl, DJ Ziegenhagen, W Kruis
Deutsche Medizinische Wochenschrift (1946), 2005•europepmc.orgResults Common bile duct diameter was significantly larger after a standard meal with
hymecromone given po or iv than with placebo (each p< 0.01). However, alterations in gall
bladder volume after a standard meal were not different between placebo and
hymecromone (po or iv). Unconjugated and conjugated bile acids rose after standard meal
in all three groups without significant differences between hymecromone and placebo.
Conclusions Hymecromone was associated with significant dilation of the common bile duct …
hymecromone given po or iv than with placebo (each p< 0.01). However, alterations in gall
bladder volume after a standard meal were not different between placebo and
hymecromone (po or iv). Unconjugated and conjugated bile acids rose after standard meal
in all three groups without significant differences between hymecromone and placebo.
Conclusions Hymecromone was associated with significant dilation of the common bile duct …
Results
Common bile duct diameter was significantly larger after a standard meal with hymecromone given po or iv than with placebo (each p< 0.01). However, alterations in gall bladder volume after a standard meal were not different between placebo and hymecromone (po or iv). Unconjugated and conjugated bile acids rose after standard meal in all three groups without significant differences between hymecromone and placebo.
Conclusions
Hymecromone was associated with significant dilation of the common bile duct. In contrast to previous reports an effect of hymecromone on gall bladder motility could not be observed. The unchanged values of bile acids in serum after hymecromone compared to placebo, together with the dilatation of the common bile duct after hymecromone, may indicate a bile acid-independent effect of hymecromone on bile secretion.
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