[HTML][HTML] Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice
JM Irimia, CM Meyer, DM Segvich, S Surendran… - Journal of Biological …, 2017 - ASBMB
Disruption of the Gys2 gene encoding the liver isoform of glycogen synthase generates a
mouse strain (LGSKO) that almost completely lacks hepatic glycogen, has impaired glucose
disposal, and is pre-disposed to entering the fasted state. This study investigated how the
lack of liver glycogen increases fat accumulation and the development of liver insulin
resistance. Insulin signaling in LGSKO mice was reduced in liver, but not muscle, suggesting
an organ-specific defect. Phosphorylation of components of the hepatic insulin-signaling …
mouse strain (LGSKO) that almost completely lacks hepatic glycogen, has impaired glucose
disposal, and is pre-disposed to entering the fasted state. This study investigated how the
lack of liver glycogen increases fat accumulation and the development of liver insulin
resistance. Insulin signaling in LGSKO mice was reduced in liver, but not muscle, suggesting
an organ-specific defect. Phosphorylation of components of the hepatic insulin-signaling …