Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a transcriptional
coactivator involved in several aspects of energy metabolism. It is induced or activated
under different stimuli in a highly tissue-specific manner and subsequently partners with
certain transcription factors in those tissues to execute various biological programs. In the
fasted liver, PGC-1α is induced and interacts with hepatocyte nuclear factor 4α (HNF4α) and
other transcription factors to activate gluconeogenesis and increase hepatic glucose output …