[HTML][HTML] Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice [S]
AB Oteng, PMM Ruppert, L Boutens, W Dijk… - Journal of Lipid …, 2019 - ASBMB
Angiopoietin-like protein (ANGPTL) 4 regulates plasma lipids, making it an attractive target
for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet
causes chylous ascites, an acute-phase response, and mesenteric lymphadenopathy. Here,
we studied the role of ANGPTL4 in lipid uptake in macrophages and in the above-mentioned
pathologies using Angptl4-hypomorphic and Angptl4−/− mice. Angptl4 expression in
peritoneal and bone marrow-derived macrophages was highly induced by lipids …
for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet
causes chylous ascites, an acute-phase response, and mesenteric lymphadenopathy. Here,
we studied the role of ANGPTL4 in lipid uptake in macrophages and in the above-mentioned
pathologies using Angptl4-hypomorphic and Angptl4−/− mice. Angptl4 expression in
peritoneal and bone marrow-derived macrophages was highly induced by lipids …