Disruption of renal arginine metabolism promotes kidney injury in hepatorenal syndrome in mice
Bile acids activate farnesoid X receptor (FXR) and G protein–coupled bile acid receptor‐1
(aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile acid metabolism and
glucose and insulin sensitivity. FXR and TGR5 are coexpressed in the enteroendocrine L
cells, but their roles in integrated regulation of metabolism are not completely understood.
We reported recently that activation of FXR induces TGR5 to stimulate glucagon‐like peptide‐
1 (GLP‐1) secretion to improve insulin sensitivity and hepatic metabolism. In this study, we …
(aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile acid metabolism and
glucose and insulin sensitivity. FXR and TGR5 are coexpressed in the enteroendocrine L
cells, but their roles in integrated regulation of metabolism are not completely understood.
We reported recently that activation of FXR induces TGR5 to stimulate glucagon‐like peptide‐
1 (GLP‐1) secretion to improve insulin sensitivity and hepatic metabolism. In this study, we …