Background & Aims Macrophages contribute to liver disease, but their role in cholestatic
liver injury, including primary sclerosing cholangitis (PSC), is unclear. We tested the
hypothesis that macrophages contribute to the pathogenesis of, and are therapeutic targets
for, PSC. Methods Immune cell profile, hepatic macrophage number, localization and
polarization, fibrosis, and serum markers of liver injury and cholestasis were measured in an
acute (intrabiliary injection of the inhibitor of apoptosis antagonist BV6) and chronic …