Background & Aims Hepatic recruitment of monocyte-derived macrophages (MoMFs)
contributes to the inflammatory response in non-alcoholic steatohepatitis (NASH). However,
how hepatocyte lipotoxicity promotes MoMF inflammation is unclear. Here we demonstrate
that lipotoxic hepatocyte-derived extracellular vesicles (LPC-EVs) are enriched with active
integrin β 1 (ITGβ 1), which promotes monocyte adhesion and liver inflammation in murine
NASH. Methods Hepatocytes were treated with either vehicle or the toxic lipid mediator …