A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis
A Hammoutene, L Biquard, J Lasselin, M Kheloufi… - Journal of …, 2020 - Elsevier
Background & Aims Previous studies demonstrated that autophagy is protective in
hepatocytes and macrophages, but detrimental in hepatic stellate cells in chronic liver
diseases. The role of autophagy in liver sinusoidal endothelial cells (LSECs) in non-
alcoholic steatohepatitis (NASH) is unknown. Our aim was to analyze the potential
implication of autophagy in LSECs in NASH and liver fibrosis. Methods We analyzed
autophagy in LSECs from patients using transmission electron microscopy. We determined …
hepatocytes and macrophages, but detrimental in hepatic stellate cells in chronic liver
diseases. The role of autophagy in liver sinusoidal endothelial cells (LSECs) in non-
alcoholic steatohepatitis (NASH) is unknown. Our aim was to analyze the potential
implication of autophagy in LSECs in NASH and liver fibrosis. Methods We analyzed
autophagy in LSECs from patients using transmission electron microscopy. We determined …