[HTML][HTML] Role of accessory factors and steroid receptor coactivator 1 in the regulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids
JM Stafford, M Waltner-Law, DK Granner - Journal of Biological Chemistry, 2001 - ASBMB
In the liver, glucocorticoids induce a 10–15-fold increase in the rate of transcription of the
phosphoenolpyruvate carboxykinase (PEPCK) gene, which encodes a key gluconeogenic
enzyme. This induction requires a multicomponent glucocorticoid response unit (GRU)
comprised of four glucocorticoid accessory factor (AF) elements and two glucocorticoid
receptor binding sites. We show that the AFs that bind the gAF1, gAF2, and gAF3 elements
(hepatocyte nuclear factor [HNF] 4/chicken ovalbumin upstream promoter transcription factor …
phosphoenolpyruvate carboxykinase (PEPCK) gene, which encodes a key gluconeogenic
enzyme. This induction requires a multicomponent glucocorticoid response unit (GRU)
comprised of four glucocorticoid accessory factor (AF) elements and two glucocorticoid
receptor binding sites. We show that the AFs that bind the gAF1, gAF2, and gAF3 elements
(hepatocyte nuclear factor [HNF] 4/chicken ovalbumin upstream promoter transcription factor …