ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms of the digestive system: well-differentiated pancreatic non …
M Falconi, DK Bartsch, B Eriksson, G Klöppel… - …, 2012 - karger.com
Neuroendocrinology, 2012•karger.com
The WHO 2010 classification [1] distinguishes between well-differentiated neuroendocrine
tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs) of small or
large cell type. NETs are then divided according to a grading scheme based on mitotic count
or Ki67 index in NETs-G1 (with a mitotic count! 2 per 10 high-power fields (HPF) and/or^ 2%
Ki67 index), and NETs-G2 (with a mitotic count 2–20 per 10 HPF and/or 3–20% Ki67 index).
All NECs are graded G3 (with a mitotic count 1 20 per 10 HPF and/or 1 20% Ki67 index) …
tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs) of small or
large cell type. NETs are then divided according to a grading scheme based on mitotic count
or Ki67 index in NETs-G1 (with a mitotic count! 2 per 10 high-power fields (HPF) and/or^ 2%
Ki67 index), and NETs-G2 (with a mitotic count 2–20 per 10 HPF and/or 3–20% Ki67 index).
All NECs are graded G3 (with a mitotic count 1 20 per 10 HPF and/or 1 20% Ki67 index) …
The WHO 2010 classification [1] distinguishes between well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs) of small or large cell type. NETs are then divided according to a grading scheme based on mitotic count or Ki67 index in NETs-G1 (with a mitotic count! 2 per 10 high-power fields (HPF) and/or^ 2% Ki67 index), and NETs-G2 (with a mitotic count 2–20 per 10 HPF and/or 3–20% Ki67 index). All NECs are graded G3 (with a mitotic count 1 20 per 10 HPF and/or 1 20% Ki67 index). Most pancreatic NF-NENs are well differentiated (ie NETs); NF-NECs are uncommon. NF-NETs have a crude
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