Bisphosphonates: mechanisms of action

H Fleisch, A Reszka, G Rodan, M Rogers - Principles of bone biology, 2002 - Elsevier
Publisher Summary The bisphosphonates are a class of drugs developed over the past
three decades for use in various diseases of bone, tooth, and calcium metabolism.
Bisphosphonates are characterized by two C–P bonds. When the two C–P bonds are on a
single carbon atom (PCP), they are analogs of pyrophosphate (POP) and are called geminal
bisphosphonates. Only geminal bisphosphonates seem to have a strong activity on the
skeleton, and for the sake of simplicity, they are generally called bisphosphonates. The PCP …