[HTML][HTML] The polycystic kidney disease-1 gene is a target for p53-mediated transcriptional repression

D Van Bodegom, Z Saifudeen, S Dipp, S Puri… - Journal of biological …, 2006 - ASBMB
This study provides evidence that the tumor suppressor protein, p53, is a transcriptional
repressor of PKD1. Kidneys of p53-null mice expressed higher Pkd1 mRNA levels than wild-
type littermates; γ-irradiation suppressed PKD1 gene expression in p53+/+ but not p53–/–
cells; and chromatin immunoprecipitation assays demonstrated the binding of p53 to the
PKD1 promoter in vivo. In transient transfection assays, p53 repressed PKD1 promoter
activity independently of endogenous p21. Deletion analysis mapped p53-mediated …