An ancient family of RNA-binding proteins: still important!

ML Wells, L Perera, PJ Blackshear - Trends in biochemical sciences, 2017 - cell.com
ML Wells, L Perera, PJ Blackshear
Trends in biochemical sciences, 2017cell.com
RNA-binding proteins are important modulators of mRNA stability, a crucial process that
determines the ultimate cellular levels of mRNAs and their encoded proteins. The
tristetraprolin (TTP) family of RNA-binding proteins appeared early in the evolution of
eukaryotes, and has persisted in modern eukaryotes. The domain structures and
biochemical functions of family members from widely divergent lineages are remarkably
similar, but their mRNA'targets' can be very different, even in closely related species. Recent …
RNA-binding proteins are important modulators of mRNA stability, a crucial process that determines the ultimate cellular levels of mRNAs and their encoded proteins. The tristetraprolin (TTP) family of RNA-binding proteins appeared early in the evolution of eukaryotes, and has persisted in modern eukaryotes. The domain structures and biochemical functions of family members from widely divergent lineages are remarkably similar, but their mRNA 'targets' can be very different, even in closely related species. Recent gene knockout studies in species as distantly related as plants, flies, yeasts, and mice have demonstrated crucial roles for these proteins in a wide variety of physiological processes. Inflammatory and hematopoietic phenotypes in mice have suggested potential therapeutic approaches for analogous human disorders.
cell.com