[HTML][HTML] Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis
N Hattori, DA Carrino, ME Lauer, A Vasanji… - Journal of Biological …, 2011 - ASBMB
The cell and its glycosaminoglycan-rich pericellular matrix (PCM) comprise a functional unit.
Because modification of PCM influences cell behavior, we investigated molecular
mechanisms that regulate PCM volume and composition. In fibroblasts and other cells,
aggregates of hyaluronan and versican are found in the PCM. Dermal fibroblasts from
Adamts5−/− mice, which lack a versican-degrading protease, ADAMTS5, had reduced
versican proteolysis, increased PCM, altered cell shape, enhanced α-smooth muscle actin …
Because modification of PCM influences cell behavior, we investigated molecular
mechanisms that regulate PCM volume and composition. In fibroblasts and other cells,
aggregates of hyaluronan and versican are found in the PCM. Dermal fibroblasts from
Adamts5−/− mice, which lack a versican-degrading protease, ADAMTS5, had reduced
versican proteolysis, increased PCM, altered cell shape, enhanced α-smooth muscle actin …