[HTML][HTML] Matrix metalloproteinase processing of CXCL11/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding
JH Cox, RA Dean, CR Roberts, CM Overall - Journal of biological chemistry, 2008 - ASBMB
The CXCR3 chemokine receptor regulates the migration of Th1 lymphocytes and responds
to three ligands: CXCL9/MIG, CXCL10/IP-10, and CXCL11/I-TAC. We screened for potential
regulation of T cell responses by matrix metalloproteinase (MMP) processing of these
important chemokines. The most potent of the CXCR3 ligands, CXCL11, was identified by
matrix-assisted laser desorption ionization time-of-flight mass spectrometry as a substrate of
the PMN-specific MMP-8, macrophage-specific MMP-12, and the general leukocyte MMP-9 …
to three ligands: CXCL9/MIG, CXCL10/IP-10, and CXCL11/I-TAC. We screened for potential
regulation of T cell responses by matrix metalloproteinase (MMP) processing of these
important chemokines. The most potent of the CXCR3 ligands, CXCL11, was identified by
matrix-assisted laser desorption ionization time-of-flight mass spectrometry as a substrate of
the PMN-specific MMP-8, macrophage-specific MMP-12, and the general leukocyte MMP-9 …