[HTML][HTML] Glycosylation mediates up-regulation of a potent antiangiogenic and proatherogenic protein, thrombospondin-1, by glucose in vascular smooth muscle cells
P Raman, I Krukovets, TE Marinic, P Bornstein… - Journal of biological …, 2007 - ASBMB
Accelerated development of atherosclerotic lesions remains the most frequent and
dangerous complication of diabetes, accounting for 80% of deaths among diabetics.
However, our understanding of the pathways mediating glucose-induced gene expression
in vascular cells remains controversial and incomplete. We have identified an intracellular
metabolic pathway activated by high glucose in human aortic smooth muscle cells that
mediates up-regulation of thrombospondin-1 (TSP-1). TSP-1 is a potent antiangiogenic and …
dangerous complication of diabetes, accounting for 80% of deaths among diabetics.
However, our understanding of the pathways mediating glucose-induced gene expression
in vascular cells remains controversial and incomplete. We have identified an intracellular
metabolic pathway activated by high glucose in human aortic smooth muscle cells that
mediates up-regulation of thrombospondin-1 (TSP-1). TSP-1 is a potent antiangiogenic and …