[HTML][HTML] Hyperplasia of pancreatic beta cells and improved glucose tolerance in mice deficient in the FXYD2 subunit of Na, K-ATPase

E Arystarkhova, YB Liu, C Salazar, V Stanojevic… - Journal of Biological …, 2013 - ASBMB
Restoration of the functional potency of pancreatic islets either through enhanced
proliferation (hyperplasia) or increase in size (hypertrophy) of beta cells is a major objective
for intervention in diabetes. We have obtained experimental evidence that global knock-out
of a small, single-span regulatory subunit of Na, K-ATPase, FXYD2, alters glucose control.
Adult Fxyd2−/− mice showed significantly lower blood glucose levels, no signs of peripheral
insulin resistance, and improved glucose tolerance compared with their littermate controls …