[HTML][HTML] Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis …
F Oger, J Dubois-Chevalier, C Gheeraert… - Journal of Biological …, 2014 - ASBMB
The nuclear receptor peroxisome proliferator-activated receptor (PPAR) γ is a transcription
factor whose expression is induced during adipogenesis and that is required for the
acquisition and control of mature adipocyte functions. Indeed, PPARγ induces the
expression of genes involved in lipid synthesis and storage through enhancers activated
during adipocyte differentiation. Here, we show that PPARγ also binds to enhancers already
active in preadipocytes as evidenced by an active chromatin state including lower DNA …
factor whose expression is induced during adipogenesis and that is required for the
acquisition and control of mature adipocyte functions. Indeed, PPARγ induces the
expression of genes involved in lipid synthesis and storage through enhancers activated
during adipocyte differentiation. Here, we show that PPARγ also binds to enhancers already
active in preadipocytes as evidenced by an active chromatin state including lower DNA …