Transcriptional regulatory circuits controlling brown fat development and activation
P Seale - Diabetes, 2015 - Am Diabetes Assoc
P Seale
Diabetes, 2015•Am Diabetes AssocBrown and beige adipose tissue is specialized for heat production and can be activated to
reduce obesity and metabolic dysfunction in animals. Recent studies also have indicated
that human brown fat activity levels correlate with leanness. This has revitalized interest in
brown fat biology and has driven the discovery of many new regulators of brown fat
development and function. This review summarizes recent advances in our understanding of
the transcriptional mechanisms that control brown and beige fat cell development.
reduce obesity and metabolic dysfunction in animals. Recent studies also have indicated
that human brown fat activity levels correlate with leanness. This has revitalized interest in
brown fat biology and has driven the discovery of many new regulators of brown fat
development and function. This review summarizes recent advances in our understanding of
the transcriptional mechanisms that control brown and beige fat cell development.
Brown and beige adipose tissue is specialized for heat production and can be activated to reduce obesity and metabolic dysfunction in animals. Recent studies also have indicated that human brown fat activity levels correlate with leanness. This has revitalized interest in brown fat biology and has driven the discovery of many new regulators of brown fat development and function. This review summarizes recent advances in our understanding of the transcriptional mechanisms that control brown and beige fat cell development.
Am Diabetes Assoc