[HTML][HTML] Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate
M Bouly, D Masson, B Gross, X Jiang, C Fievet… - Journal of Biological …, 2001 - ASBMB
Fibrate treatment in mice is known to modulate high density lipoprotein (HDL) metabolism by
regulating apolipoprotein (apo) AI and apoAII gene expression. In addition to alterations in
plasma HDL levels, fibrates induce the emergence of large, cholesteryl ester-rich HDL in
treated transgenic mice expressing human apoAI (HuAITg). The mechanisms of these
changes may not be restricted to the modulation of apolipoprotein gene expression, and the
aim of the present study was to determine whether the expression of factors known to affect …
regulating apolipoprotein (apo) AI and apoAII gene expression. In addition to alterations in
plasma HDL levels, fibrates induce the emergence of large, cholesteryl ester-rich HDL in
treated transgenic mice expressing human apoAI (HuAITg). The mechanisms of these
changes may not be restricted to the modulation of apolipoprotein gene expression, and the
aim of the present study was to determine whether the expression of factors known to affect …