[HTML][HTML] Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor α activators
N Vu-Dac, P Gervois, H Jakel, M Nowak… - Journal of Biological …, 2003 - ASBMB
The recently discovered APOA5 gene has been shown in humans and mice to be important
in determining plasma triglyceride levels, a major cardiovascular disease risk factor. apoAV
represents the first described apolipoprotein where overexpression lowers triglyceride
levels. Since fibrates represent a commonly used therapy for lowering plasma triglycerides
in humans, we investigated their ability to modulate APOA5 gene expression and
consequently influence plasma triglyceride levels. Human primary hepatocytes treated with …
in determining plasma triglyceride levels, a major cardiovascular disease risk factor. apoAV
represents the first described apolipoprotein where overexpression lowers triglyceride
levels. Since fibrates represent a commonly used therapy for lowering plasma triglycerides
in humans, we investigated their ability to modulate APOA5 gene expression and
consequently influence plasma triglyceride levels. Human primary hepatocytes treated with …