[HTML][HTML] Protein phosphatase PP5 controls bone mass and the negative effects of rosiglitazone on bone through reciprocal regulation of PPARγ (peroxisome …
Peroxisome proliferator-activated receptor γ (PPARγ) and runt-related transcription factor 2
(RUNX2) are key regulators of mesenchymal stem cell (MSC) differentiation toward
adipocytes and osteoblasts, respectively. Post-translational modifications of these factors
determine their activities. Dephosphorylation of PPARγ at Ser-112 is required for its
adipocytic activity, whereas phosphorylation of RUNX2 at serine 319 (Ser-319) promotes its
osteoblastic activity. Here we show that protein phosphatase 5 (PP5) reciprocally regulates …
(RUNX2) are key regulators of mesenchymal stem cell (MSC) differentiation toward
adipocytes and osteoblasts, respectively. Post-translational modifications of these factors
determine their activities. Dephosphorylation of PPARγ at Ser-112 is required for its
adipocytic activity, whereas phosphorylation of RUNX2 at serine 319 (Ser-319) promotes its
osteoblastic activity. Here we show that protein phosphatase 5 (PP5) reciprocally regulates …