[HTML][HTML] ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the …
Mutations in the ATP-binding cassette transporter A1 (ABCA1) transporter are associated
with Tangier disease and a defect in cellular cholesterol efflux. The amino terminus of the
ABCA1 transporter has two putative in-frame translation initiation sites, 60 amino acids
apart. A cluster of hydrophobic amino acids form a potentially cleavable signal sequence in
this 60-residue extension. We investigated the functional role of this extension and found
that it was required for stable protein expression of transporter constructs containing any …
with Tangier disease and a defect in cellular cholesterol efflux. The amino terminus of the
ABCA1 transporter has two putative in-frame translation initiation sites, 60 amino acids
apart. A cluster of hydrophobic amino acids form a potentially cleavable signal sequence in
this 60-residue extension. We investigated the functional role of this extension and found
that it was required for stable protein expression of transporter constructs containing any …