Integrative genomics identifies novel associations with APOL1 risk genotypes in black NEPTUNE subjects
MG Sampson, CC Robertson, S Martini… - Journal of the …, 2016 - journals.lww.com
APOL1 variants have been associated with renal phenotypes in blacks. To refine clinical
outcomes and discover mechanisms of APOL1-associated kidney injury, we analyzed
clinical and genomic datasets derived from 90 black subjects in the Nephrotic Syndrome
Study Network (NEPTUNE), stratified by APOL1 risk genotype. Ninety subjects with
proteinuria≥ 0.5 g/d were enrolled at first biopsy for primary nephrotic syndrome and
followed. Clinical outcomes were determined, and renal histomorphometry and sequencing …
outcomes and discover mechanisms of APOL1-associated kidney injury, we analyzed
clinical and genomic datasets derived from 90 black subjects in the Nephrotic Syndrome
Study Network (NEPTUNE), stratified by APOL1 risk genotype. Ninety subjects with
proteinuria≥ 0.5 g/d were enrolled at first biopsy for primary nephrotic syndrome and
followed. Clinical outcomes were determined, and renal histomorphometry and sequencing …