[HTML][HTML] p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun: The determinant role of the isoforms in the p38 MAPK signal …
R Pramanik, X Qi, S Borowicz, D Choubey… - Journal of Biological …, 2003 - ASBMB
p38 MAPK pathway signaling is known to participate in cell proliferation, apoptosis, and
differentiation, in a manner dependent on the cellular context. The factors that determine the
specific biological response in a given cell type, however, remain largely unknown. We
report opposite effects of the p38 isoforms on regulation of AP-1-dependent activities by p38
activators MAPK kinase 6 (MKK6) and/or arsenite in human breast cancer cells. The p38β
isoform increases the activation of AP-1 transcriptional activities by MKK6 and/or arsenite …
differentiation, in a manner dependent on the cellular context. The factors that determine the
specific biological response in a given cell type, however, remain largely unknown. We
report opposite effects of the p38 isoforms on regulation of AP-1-dependent activities by p38
activators MAPK kinase 6 (MKK6) and/or arsenite in human breast cancer cells. The p38β
isoform increases the activation of AP-1 transcriptional activities by MKK6 and/or arsenite …