Kidney injury molecule‐1 in renal disease

F Waanders, MM van Timmeren… - The Journal of …, 2010 - Wiley Online Library
F Waanders, MM van Timmeren, CA Stegeman, SJL Bakker, H van Goor
The Journal of Pathology: A Journal of the Pathological Society of …, 2010Wiley Online Library
Abstract Kidney injury molecule‐1 (KIM‐1) is a marker for renal proximal tubular damage,
the hallmark of virtually all proteinuric, toxic and ischaemic kidney diseases. KIM‐1 has
gained increasing interest because of its possible pathophysiological role in modulating
tubular damage and repair. In this respect, it is interesting that the best biomarkers often turn
out to be important in modulation of damage and some even become therapeutic targets.
The emphasis of this review is on structural and biochemical aspects of KIM‐1, its …
Abstract
Kidney injury molecule‐1 (KIM‐1) is a marker for renal proximal tubular damage, the hallmark of virtually all proteinuric, toxic and ischaemic kidney diseases. KIM‐1 has gained increasing interest because of its possible pathophysiological role in modulating tubular damage and repair. In this respect, it is interesting that the best biomarkers often turn out to be important in modulation of damage and some even become therapeutic targets. The emphasis of this review is on structural and biochemical aspects of KIM‐1, its expression pattern and its pathophysiological role in renal disease. We also discuss the prognostic impact of KIM‐1 in relation to urinary protein excretion. Glomerular (proteinuria) and interstitial markers (KIM‐1) might have independent prognostic impact and so may provide independent treatment targets. Finally, the potential of KIM‐1 as biomarker of renal damage, as a predictor of renal function decline and its perspectives for monitoring therapy response, are discussed. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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