Inherited podocytopathies: FSGS and nephrotic syndrome from a genetic viewpoint

MR Pollak - Journal of the American Society of Nephrology, 2002 - journals.lww.com
Recent progress in defining the genetic basis of inherited glomerular disease has helped
illuminate inadequacies in the way we describe many of these diseases. Too often, we talk
about histologic patterns of injury, such as focal and segmental glomerulosclerosis (FSGS),
as if they were diseases rather than descriptions of kidney biopsy specimens at particular
points in time. Some patients “with FSGS” respond to steroids, some do not; some patients
present with nephrotic syndrome (NS), others with mild proteinuria; some present in …