Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.
L Schomburg, U Schweizer, B Holtmann… - Biochemical …, 2003 - ncbi.nlm.nih.gov
Biochemical Journal, 2003•ncbi.nlm.nih.gov
Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in
selenium transport, selenium detoxification or antioxidant defence. We generated SePP-
knockout mice that were viable, but exhibited reduced growth and developed ataxia.
Selenium content was elevated in liver, but low in plasma and other tissues, and
selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role
in delivering hepatic selenium to target tissues.
selenium transport, selenium detoxification or antioxidant defence. We generated SePP-
knockout mice that were viable, but exhibited reduced growth and developed ataxia.
Selenium content was elevated in liver, but low in plasma and other tissues, and
selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role
in delivering hepatic selenium to target tissues.
Abstract
Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.
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