Stem cells, megakaryocytes, and platelets
BW Smith, GJ Murphy - Current opinion in hematology, 2014 - journals.lww.com
BW Smith, GJ Murphy
Current opinion in hematology, 2014•journals.lww.comStudies that utilize stem cells for the efficient derivation of megakaryocytes and platelets
have played a role in uncovering novel molecular mechanisms of megakaryopoiesis,
modeling and correcting relevant diseases, and differentiating platelets that are functional
and scalable for translation into the clinic. Efforts to derive megakaryocytes and platelets
from pluripotent stem cells foster the opportunity of a revolutionary cellular therapy for the
treatment of multiple platelet-associated diseases.
have played a role in uncovering novel molecular mechanisms of megakaryopoiesis,
modeling and correcting relevant diseases, and differentiating platelets that are functional
and scalable for translation into the clinic. Efforts to derive megakaryocytes and platelets
from pluripotent stem cells foster the opportunity of a revolutionary cellular therapy for the
treatment of multiple platelet-associated diseases.
Summary
Studies that utilize stem cells for the efficient derivation of megakaryocytes and platelets have played a role in uncovering novel molecular mechanisms of megakaryopoiesis, modeling and correcting relevant diseases, and differentiating platelets that are functional and scalable for translation into the clinic. Efforts to derive megakaryocytes and platelets from pluripotent stem cells foster the opportunity of a revolutionary cellular therapy for the treatment of multiple platelet-associated diseases.
Lippincott Williams & Wilkins