Membrane lipid rafts play a key role in immune cell activation by recruiting and excluding
specific signaling components of immune cell surface receptors upon the receptor
engagement. Despite this, the role of these microdomains in the regulation of osteoclasts as
controlled by receptor activator of nuclear factor κB (RANK) has yet to be established. In this
study, we demonstrate that the raft microdomain expression plays an essential role in
osteoclast function and differentiation. Expression of raft component flotillin greatly …