[HTML][HTML] Lactosylceramide is essential for the osteoclastogenesis mediated by macrophage-colony-stimulating factor and receptor activator of nuclear factor-κB ligand
T Iwamoto, S Fukumoto, K Kanaoka, E Sakai… - Journal of Biological …, 2001 - ASBMB
Glycosphingolipids and their metabolites play important roles in a variety of biological
processes. Several signal molecules are localized in a glycolipid-enriched microdomain on
the cell surface, and their signals are regulated by the glycolipid composition. However, the
function of glycolipids in osteoclastogenesis has not been clearly understood. We found
thatd-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (d-PDMP), a
glucosylceramide synthase inhibitor, completely inhibits the osteoclast formation induced by …
processes. Several signal molecules are localized in a glycolipid-enriched microdomain on
the cell surface, and their signals are regulated by the glycolipid composition. However, the
function of glycolipids in osteoclastogenesis has not been clearly understood. We found
thatd-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (d-PDMP), a
glucosylceramide synthase inhibitor, completely inhibits the osteoclast formation induced by …
