EP3 receptor-mediated contraction of human pulmonary arteries and inhibition of neurogenic tachycardia in pithed rats
H Kozłowska, M Baranowska-Kuczko, E Schlicker… - Pharmacological …, 2012 - Elsevier
Background The aim of our study was (1) the pharmacological characterization of EP 3
receptors in human pulmonary arteries and (2) the examination of the potential involvement
of these receptors in the regulation of neurogenic tachycardia in pithed rats. L-826266
served as the EP3 receptor antagonist. Methods Experiments were performed on isolated
human pulmonary arteries and pithed rats. Results The prostanoid EP 1/EP 3 receptor
agonist sulprostone (1 nM–100 μM) concentration-dependently contracted isolated human …
receptors in human pulmonary arteries and (2) the examination of the potential involvement
of these receptors in the regulation of neurogenic tachycardia in pithed rats. L-826266
served as the EP3 receptor antagonist. Methods Experiments were performed on isolated
human pulmonary arteries and pithed rats. Results The prostanoid EP 1/EP 3 receptor
agonist sulprostone (1 nM–100 μM) concentration-dependently contracted isolated human …