[HTML][HTML] Postnatal dietary fatty acid composition permanently affects the structure of hypothalamic pathways controlling energy balance in mice
L Schipper, K Bouyer, A Oosting, RB Simerly… - The American journal of …, 2013 - Elsevier
Background: We previously reported that dietary lipid quality during early life can have long-
lasting effects on metabolic health and adiposity. Exposure to a postnatal diet with low
dietary omega-6 (n− 6) or high omega-3 (n− 3) fatty acid (FA) content resulted in reduced
body fat accumulation when challenged with a moderate Western-style diet (WSD)
beginning in adolescence. Objective: We determined whether this programming effect is
accompanied by changes in hypothalamic neural projections or modifications in the …
lasting effects on metabolic health and adiposity. Exposure to a postnatal diet with low
dietary omega-6 (n− 6) or high omega-3 (n− 3) fatty acid (FA) content resulted in reduced
body fat accumulation when challenged with a moderate Western-style diet (WSD)
beginning in adolescence. Objective: We determined whether this programming effect is
accompanied by changes in hypothalamic neural projections or modifications in the …