[HTML][HTML] Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal
J Taylor, SK Grote, J Xia, M Vandelft, J Graczyk… - Journal of Biological …, 2006 - ASBMB
Spinocerebellar ataxia type 7 is a progressive neurodegenerative disorder caused by a
CAG DNA triplet repeat expansion leading to an expanded polyglutamine tract in the ataxin-
7 protein. Ataxin-7 appears to be a transcription factor and a component of the STAGA
transcription coactivator complex. Here, using live cell imaging and inverted fluorescence
recovery after photobleaching, we demonstrate that ataxin-7 has the ability to export from the
nucleus via the CRM-1/exportin pathway and that ataxin-7 contains a classic leucine-type …
CAG DNA triplet repeat expansion leading to an expanded polyglutamine tract in the ataxin-
7 protein. Ataxin-7 appears to be a transcription factor and a component of the STAGA
transcription coactivator complex. Here, using live cell imaging and inverted fluorescence
recovery after photobleaching, we demonstrate that ataxin-7 has the ability to export from the
nucleus via the CRM-1/exportin pathway and that ataxin-7 contains a classic leucine-type …