Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis
PE Marik, JC Preiser - Chest, 2010 - Elsevier
Background Following publication of the Leuven Intensive Insulin Therapy Trial in 2001,
tight glycemic control became the standard of care in ICUs around the world. Recent studies
suggest that this approach may be flawed. The goal of this systematic review was to
determine the benefits and risks of tight glycemic control in ICU patients and to explain the
differences in outcomes among reported trials. Methods Prospective, randomized controlled
clinical trials (RCTs) that studied the impact of tight glycemic control (blood glucose 80-110 …
tight glycemic control became the standard of care in ICUs around the world. Recent studies
suggest that this approach may be flawed. The goal of this systematic review was to
determine the benefits and risks of tight glycemic control in ICU patients and to explain the
differences in outcomes among reported trials. Methods Prospective, randomized controlled
clinical trials (RCTs) that studied the impact of tight glycemic control (blood glucose 80-110 …