[HTML][HTML] Repression of inflammasome by Francisella tularensis during early stages of infection
RJ Dotson, SM Rabadi, EL Westcott, S Bradley… - Journal of Biological …, 2013 - ASBMB
Francisella tularensis is an important human pathogen responsible for causing tularemia. F.
tularensis has long been developed as a biological weapon and is now classified as a
category A agent by the Centers for Disease Control because of its possible use as a
bioterror agent. F. tularensis represses inflammasome; a cytosolic multi-protein complex that
activates caspase-1 to produce proinflammatory cytokines IL-1β and IL-18. However, the
Francisella factors and the mechanisms through which F. tularensis mediates these …
tularensis has long been developed as a biological weapon and is now classified as a
category A agent by the Centers for Disease Control because of its possible use as a
bioterror agent. F. tularensis represses inflammasome; a cytosolic multi-protein complex that
activates caspase-1 to produce proinflammatory cytokines IL-1β and IL-18. However, the
Francisella factors and the mechanisms through which F. tularensis mediates these …