[HTML][HTML] Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1β
P Schotte, G Denecker, A Van Den Broeke… - Journal of Biological …, 2004 - ASBMB
Yersinia bacteria can take control of the host cell by injecting so-called Yop effector proteins
into the cytosol of the cells to which they adhere. Using Yersinia enterocolitica strains that
are deficient for one or more Yops, we could show that YopE and, to a lesser extent, YopT
interfere with the caspase-1-mediated maturation of prointerleukin-1β in macrophages. In
addition, overexpression of YopE and YopT was shown to prevent the autoproteolytic
activation of caspase-1 in a way that is dependent on their inhibitory effect on Rho GTPases …
into the cytosol of the cells to which they adhere. Using Yersinia enterocolitica strains that
are deficient for one or more Yops, we could show that YopE and, to a lesser extent, YopT
interfere with the caspase-1-mediated maturation of prointerleukin-1β in macrophages. In
addition, overexpression of YopE and YopT was shown to prevent the autoproteolytic
activation of caspase-1 in a way that is dependent on their inhibitory effect on Rho GTPases …