Dendritic spines are major sites to receive synapses in the mammalian brain. Spines with
abnormal morphologies are found in different brain diseases, suggesting that malformation
of dendritic spines could be causally linked to those diseases. Rho GTPase‐signaling
pathways are implicated in the regulation of spine morphology and also in some forms of
mental retardation. Therefore, understanding the dynamic regulation of spine morphology by
Rho GTPases may provide insights into the etiology and therapeutic strategy of brain …