Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides
NR Soman, GM Lanza, JM Heuser, PH Schlesinger… - Nano …, 2008 - ACS Publications
NR Soman, GM Lanza, JM Heuser, PH Schlesinger, SA Wickline
Nano letters, 2008•ACS PublicationsThe therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic
degradation. We report the first stable incorporation of melittin (a 26 amino acid amphipathic
peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly
to the nanoparticles (dissociation constant∼ 3.27 nM) and retains its pore-forming activity
after contact-mediated delivery to model bilayer membrane (liposomes) thereby
demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for …
degradation. We report the first stable incorporation of melittin (a 26 amino acid amphipathic
peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly
to the nanoparticles (dissociation constant∼ 3.27 nM) and retains its pore-forming activity
after contact-mediated delivery to model bilayer membrane (liposomes) thereby
demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for …
The therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic degradation. We report the first stable incorporation of melittin (a 26 amino acid amphipathic peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly to the nanoparticles (dissociation constant ∼3.27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.
ACS Publications